Issue 3, 2017

Photoacoustic probes for real-time tracking of endogenous H2S in living mice

Abstract

H2S is a key chemical mediator that exerts a vital role in diverse physiological and pathological processes. However, in vivo tracking of endogenous H2S generation still remains difficult due to the lack of reliable analytical methods. Herein, we present the first example of activatable photoacoustic probes for real-time imaging of H2S in living mice through the full utilization of the superiority of photoacoustic imaging modality at fine spatial resolution during deep tissue penetration. The designed probe can generate high NIR absorption at 780 nm in the presence of H2S, thus producing a strong photoacoustic signal output in the NIR region. Furthermore, this probe exhibits extremely fast and highly selective responsiveness, good water-solubility and excellent biocompatibility. In light of these outstanding features, this probe realizes the direct photoacoustic trapping of endogenous H2S generation in a HCT116 tumor-bearing mouse model. These preliminary imaging studies show that HCT116 colon tumors exhibit CBS upregulation activity, resulting in an increased rate of H2S generation.

Graphical abstract: Photoacoustic probes for real-time tracking of endogenous H2S in living mice

Supplementary files

Article information

Article type
Edge Article
Submitted
21 Oct 2016
Accepted
26 Nov 2016
First published
30 Nov 2016
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2017,8, 2150-2155

Photoacoustic probes for real-time tracking of endogenous H2S in living mice

B. Shi, X. Gu, Q. Fei and C. Zhao, Chem. Sci., 2017, 8, 2150 DOI: 10.1039/C6SC04703C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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