Issue 41, 2016

Nanoparticle delivery systems for siRNA-based therapeutics

Abstract

RNA interference (RNAi) is a naturally occurring endogenous regulatory process in which the short double-stranded RNA causes sequence-specific post-transcriptional gene silencing. Small interfering RNA (siRNA) represents great therapeutic potential for diseases (e.g., cancer) caused by abnormal gene overexpression or mutation. The major challenge in using RNAi for disease therapy is the targeted and effective delivery of siRNA in vivo. The development of nanotechnology with the important progress in nanoparticle-mediated delivery systems promises efficient intracellular siRNA delivery. This review summarizes the recent advances in nanoparticle delivery systems for siRNA-based therapeutics.

Graphical abstract: Nanoparticle delivery systems for siRNA-based therapeutics

Article information

Article type
Review Article
Submitted
14 Jun 2016
Accepted
21 Aug 2016
First published
22 Aug 2016

J. Mater. Chem. B, 2016,4, 6620-6639

Nanoparticle delivery systems for siRNA-based therapeutics

J. Li, S. Xue and Z. Mao, J. Mater. Chem. B, 2016, 4, 6620 DOI: 10.1039/C6TB01462C

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