Issue 4, 2018

Interaction of cells with patterned reactors

Abstract

Surface coatings that allow externally controlled interaction with cells are of interested for diverse biomedical applications. We fabricated particle patterns and assessed the interaction of these substrates with endothelial cells and hepatocytes. The particles were turned into subcompartmentalized reactors by immobilizing glucose oxidase loaded liposomes sandwiched between polymer layers. The reactor activities depending on the number of liposome deposition steps were confirmed in solution and on patterned surfaces. Finally, reduced viability of hepatocytes adhering to the reactor patterned surfaces in the presence of glucose was observed due to the local production of hydrogen peroxide. This first report on patterned reactors in combination with cells opens up vast opportunities to assemble interactive nanobiointerfaces.

Graphical abstract: Interaction of cells with patterned reactors

Supplementary files

Article information

Article type
Paper
Submitted
12 Sep 2017
Accepted
09 Dec 2017
First published
11 Dec 2017

Biomater. Sci., 2018,6, 793-802

Interaction of cells with patterned reactors

C. Zhu, E. M. Taipaleenmäki, Y. Zhang, X. Han and B. Städler, Biomater. Sci., 2018, 6, 793 DOI: 10.1039/C7BM00838D

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