Issue 15, 2017

Tailor-made synthesis of fully alkylated/arylated nicotinates by FeCl3-mediated condensation of enamino esters with enones

Abstract

A new method for synthesizing polyalkylated/arylated nicotinates is established using a condensation of enamino esters with enones in the presence of FeCl3. This method facilitates the introduction of alkyl or aryl groups at any position on demand, which has not been achieved by other procedures.

Graphical abstract: Tailor-made synthesis of fully alkylated/arylated nicotinates by FeCl3-mediated condensation of enamino esters with enones

Supplementary files

Article information

Article type
Communication
Submitted
04 Jan 2017
Accepted
03 Feb 2017
First published
03 Feb 2017

Chem. Commun., 2017,53, 2390-2393

Tailor-made synthesis of fully alkylated/arylated nicotinates by FeCl3-mediated condensation of enamino esters with enones

S. Hirai, Y. Horikawa, H. Asahara and N. Nishiwaki, Chem. Commun., 2017, 53, 2390 DOI: 10.1039/C7CC00051K

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