Issue 27, 2017

Stabilizing the monomeric amyloid-β peptide by tyrocidine A prevents and reverses amyloidogenesis without the accumulation of oligomers

Abstract

Amyloid-β (Aβ) oligomers are causative agents triggering AD pathogenesis, but their elimination remains challenging. We herein reported a natural cyclopeptide tyrocidine A prevents and reverses amyloidogenesis without Aβ oligomer accumulation by stabilizing the monomeric, but not the oligomeric state of Aβ peptides.

Graphical abstract: Stabilizing the monomeric amyloid-β peptide by tyrocidine A prevents and reverses amyloidogenesis without the accumulation of oligomers

Supplementary files

Article information

Article type
Communication
Submitted
19 Jan 2017
Accepted
13 Mar 2017
First published
13 Mar 2017

Chem. Commun., 2017,53, 3886-3889

Stabilizing the monomeric amyloid-β peptide by tyrocidine A prevents and reverses amyloidogenesis without the accumulation of oligomers

G. Wen, W. Qin, D. Chen, Y. Wang, X. Yue, Z. Liu, Y. Cao, J. Du, B. Zhou and X. Bu, Chem. Commun., 2017, 53, 3886 DOI: 10.1039/C7CC00506G

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