Issue 26, 2017

An NIR-emitting lysosome-targeting probe with large Stokes shift via coupling cyanine and excited-state intramolecular proton transfer

Abstract

An NIR-emitting probe (λem ∼ 700 nm) with a large Stokes shift (Δλ ≈ 234 nm) is synthesized by using excited-state intramolecular proton transfer (ESIPT). The phenolic proton, which controls ESIPT, acts as a switch to give strong fluorescence at pH ≈ 5. The probe can selectively show lysosome organelles, therefore leading to a lysosome probe without exhibiting “an alkalinizing effect”.

Graphical abstract: An NIR-emitting lysosome-targeting probe with large Stokes shift via coupling cyanine and excited-state intramolecular proton transfer

Supplementary files

Article information

Article type
Communication
Submitted
24 Jan 2017
Accepted
02 Mar 2017
First published
15 Mar 2017

Chem. Commun., 2017,53, 3697-3700

An NIR-emitting lysosome-targeting probe with large Stokes shift via coupling cyanine and excited-state intramolecular proton transfer

D. Dahal, L. McDonald, X. Bi, C. Abeywickrama, F. Gombedza, M. Konopka, S. Paruchuri and Y. Pang, Chem. Commun., 2017, 53, 3697 DOI: 10.1039/C7CC00700K

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