Issue 23, 2017
From the journal:

Chemical Communications

Boronic acid-modified alginate enables direct formation of injectable, self-healing and multistimuli-responsive hydrogels†

Asja Pettignano,ab   Santiago Grijalvo,cd   Marleen Häring,a   Ramon Eritja, ORCID logo cd   Nathalie Tanchoux,b   Françoise Quignardb  and  David Díaz Díaz ORCID logo *ac  

* Corresponding authors

a Institute of Organic Chemistry, University of Regensburg, Universitaetsstr. 31, 93040 Regensburg, Germany
E-mail: david.diaz@ur.de

b Institut Charles Gerhardt, UMR 5253 CNRS/UM/ENSCM, Matériaux Avancés pour la Catalyse et la Santé, ENSCM, 8 rue Ecole Normale, 34296 Montpellier Cedex 5, France

c IQAC-CSIC, Jordi Girona 18-26, Barcelona 08034, Spain

d Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER BBN), Spain

Abstract

One-step functionalization of alginate with boronic acid groups allowed spontaneous formation of biocompatible hydrogels under basic conditions without additional complementary molecules or crosslinking agents. The dynamic nature of boronate ester bonds formed with vicinal diols present on alginate pyranose rings provided remarkable self-healing, injectable and multi-stimuli responsive properties to the material.

Graphical abstract: Boronic acid-modified alginate enables direct formation of injectable, self-healing and multistimuli-responsive hydrogels

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Article information

DOI
https://doi.org/10.1039/C7CC00765E
Article type
Communication
Submitted
27 Jan 2017
Accepted
27 Feb 2017
First published
27 Feb 2017

Chem. Commun., 2017,53, 3350-3353

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Boronic acid-modified alginate enables direct formation of injectable, self-healing and multistimuli-responsive hydrogels

A. Pettignano, S. Grijalvo, M. Häring, R. Eritja, N. Tanchoux, F. Quignard and D. Díaz Díaz, Chem. Commun., 2017, 53, 3350 DOI: 10.1039/C7CC00765E

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