SCHEDULED MAINTENANCE
Novel hypoxia-targeting Pt(iv) prodrugs†
Zichen
Xu, 
‡a
Shaohua
Gou
*a
and
‡a
Shaohua
Gou
*a
and
Abstract
Novel Pt(IV) prodrugs targeting hypoxia inducible factor HIF-1α were prepared for evaluating their antitumor activity on hypoxic cancer cells for the first time. The resulting Pt(IV) prodrug exhibited effective inhibition on tumor growth in the HCT-116 xenograft mouse model with low toxicity in vivo.
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