Issue 49, 2017
From the journal:

Chemical Communications

Specific dsDNA recognition by a mimic of the DNA binding domain of the c-Myc/Max transcription factor†

Yara Ruiz García,a   Y. Vladimir Pabon-Martinez, ORCID logo b   C. I. Edvard Smith ORCID logo b  and  Annemieke Madder ORCID logo *a  

* Corresponding authors

a Organic and Biomimetic Chemistry Research Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281, S4, Gent, Belgium
E-mail: annemieke.madder@ugent.be

b Clinical Research Center, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
E-mail: edvard.smith@ki.se

Abstract

We here report on the synthesis of the first mimic of the DNA binding domain of the c-Myc/Max-bHLH-ZIP transcription factor able to selectively recognize its cognate E-box sequence 5′-CACGTG-3′ through the major groove of the double-stranded DNA. The designed peptidosteroid conjugate was shown to be effective as DNA binder in the presence of excess competitor DNA.

Graphical abstract: Specific dsDNA recognition by a mimic of the DNA binding domain of the c-Myc/Max transcription factor

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Article information

DOI
https://doi.org/10.1039/C7CC01705G
Article type
Communication
Submitted
09 Mar 2017
Accepted
12 May 2017
First published
19 May 2017

Chem. Commun., 2017,53, 6653-6656

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Specific dsDNA recognition by a mimic of the DNA binding domain of the c-Myc/Max transcription factor

Y. Ruiz García, Y. V. Pabon-Martinez, C. I. E. Smith and A. Madder, Chem. Commun., 2017, 53, 6653 DOI: 10.1039/C7CC01705G

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