Lanthanoplatins: emissive Eu(III) and Tb(III) complexes staining nucleoli targeted through Pt–DNA crosslinking

Khushbu Singh; Swati Singh; Payal Srivastava; Sri Sivakumar; Ashis K. Patra

doi:10.1039/C7CC02047C

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Lanthanoplatins: emissive Eu(iii) and Tb(iii) complexes staining nucleoli targeted through Pt–DNA crosslinking†

Khushbu Singh,^a Swati Singh,^b Payal Srivastava,^a Sri Sivakumar

^b and Ashis K. Patra

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, Uttar Pradesh, India
E-mail: akpatra@iitk.ac.in

^b Department of Chemical Engineering and Centre for Environmental Science and Engineering, Indian Institute of Technology Kanpur, Kanpur 208016, Uttar Pradesh, India

Abstract

Two highly luminescent water-soluble heterometallic LnPt₂ complexes, [{cis-PtCl(NH₃)₂}₂Ln(L)(H₂O)](NO₃)₂ (Ln = Eu (1), Tb (2)), have been designed for their selective nucleoli staining through formation of Pt–DNA crosslinks. The complexes showed significant cellular uptake and distinctive nucleoli localization through intrinsic emission from Eu^III or Tb^III observed through confocal fluorescence microscopy.

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Article information

DOI: https://doi.org/10.1039/C7CC02047C
Article type: Communication
Submitted: 17 Mar 2017
Accepted: 12 May 2017
First published: 12 May 2017

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Chem. Commun., 2017,53, 6144-6147

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Lanthanoplatins: emissive Eu(III) and Tb(III) complexes staining nucleoli targeted through Pt–DNA crosslinking

K. Singh, S. Singh, P. Srivastava, S. Sivakumar and A. K. Patra, Chem. Commun., 2017, 53, 6144 DOI: 10.1039/C7CC02047C

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Chemical Communications

Lanthanoplatins: emissive Eu(iii) and Tb(iii) complexes staining nucleoli targeted through Pt–DNA crosslinking†

Abstract

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Lanthanoplatins: emissive Eu(III) and Tb(III) complexes staining nucleoli targeted through Pt–DNA crosslinking

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