Issue 53, 2017

Exploiting the unusual effects of fluorine in methodology

Abstract

Fluorination of organic molecules significantly impacts the basic physicochemical properties of small and large biologically active molecules, agrichemicals, and materials. Thus, the development of synthetic reactions to access these substructures is important for many applied fields of chemistry. However, these fluorine-induced perturbations of chemical properties can inhibit standard chemical transformations, which provides unique challenges for synthetic organic chemists. In addition, the physicochemical properties imparted by fluorinated substituents can enable distinct reactivity patterns relative to non-fluorinated substrates, thus making synthetic organofluorine chemistry a fertile ground for developing new, exciting transformations. In this feature article, we detail our experiences in methodology, wherein fluorinated substrates have enabled unique reactivity patterns relative to non-fluorous substrates. Specifically, we highlight the non-standard chemo- and regio-selectivities imparted by fluorinated substrates on Pd-catalyzed coupling reactions, nucleophilic addition reactions of olefins, and Cu-catalyzed decarboxylative fluoroalkylation reactions.

Graphical abstract: Exploiting the unusual effects of fluorine in methodology

Article information

Article type
Feature Article
Submitted
27 Mar 2017
Accepted
08 May 2017
First published
08 May 2017

Chem. Commun., 2017,53, 7168-7181

Exploiting the unusual effects of fluorine in methodology

D. L. Orsi and R. A. Altman, Chem. Commun., 2017, 53, 7168 DOI: 10.1039/C7CC02341C

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