Issue 50, 2017

Coordination strategy-induced selective C–H amination of 8-aminoquinolines

Abstract

In this study, we broke through the directing function of the amide group. The coordination interaction between metal and directing-group enhanced the reactivity of the substrate. Using this strategy, we realized the selective amination of 8-aminoquinolines at the C5 position via employing azoles as the source of amine. Various kinds of 8-aminoquinolines and different substituted azoles were compatible to afford the corresponding C–N coupling products.

Graphical abstract: Coordination strategy-induced selective C–H amination of 8-aminoquinolines

Supplementary files

Article information

Article type
Communication
Submitted
05 Apr 2017
Accepted
24 May 2017
First published
24 May 2017

Chem. Commun., 2017,53, 6736-6739

Coordination strategy-induced selective C–H amination of 8-aminoquinolines

H. Yi, H. Chen, C. Bian, Z. Tang, A. K. Singh, X. Qi, X. Yue, Y. Lan, J. Lee and A. Lei, Chem. Commun., 2017, 53, 6736 DOI: 10.1039/C7CC02601C

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