Issue 46, 2017

Rapid and efficient tetrazine-induced drug release from highly stable benzonorbornadiene derivatives

Abstract

A novel class of bioorthogonal release reactions based on benzonorbornadiene derivatives was developed. These carrier molecules are highly stable at physiological conditions, but react rapidly with 1,2,4,5-tetrazines, and near-quantitatively release cargo molecules such as drugs and optical reporters.

Graphical abstract: Rapid and efficient tetrazine-induced drug release from highly stable benzonorbornadiene derivatives

Supplementary files

Article information

Article type
Communication
Submitted
04 May 2017
Accepted
20 May 2017
First published
26 May 2017

Chem. Commun., 2017,53, 6271-6274

Rapid and efficient tetrazine-induced drug release from highly stable benzonorbornadiene derivatives

M. Xu, J. Tu and R. M. Franzini, Chem. Commun., 2017, 53, 6271 DOI: 10.1039/C7CC03477F

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