Issue 59, 2017

An esterase-activated click and release approach to metal-free CO-prodrugs

Abstract

One major challenge in the development of CO as a therapeutic agent is its controllable delivery in a pharmaceutically acceptable form. Herein, we describe for the first time a general chemical strategy to esterase-sensitive organic CO-prodrugs.

Graphical abstract: An esterase-activated click and release approach to metal-free CO-prodrugs

Supplementary files

Article information

Article type
Communication
Submitted
18 May 2017
Accepted
29 Jun 2017
First published
29 Jun 2017

Chem. Commun., 2017,53, 8296-8299

An esterase-activated click and release approach to metal-free CO-prodrugs

X. Ji, K. Ji, V. Chittavong, B. Yu, Z. Pan and B. Wang, Chem. Commun., 2017, 53, 8296 DOI: 10.1039/C7CC03832A

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