Co-catalyzed highly selective C(sp3)–H nitration

Abstract

A Co-catalyzed highly chemo- and regio-selective nitration of C(sp³)–H was developed. Diverse aliphatic nitro compounds were obtained in good yields, using t-BuONO as a nitrating reagent. Specific nitration of C(sp³)–H instead of C(sp²)–H was achieved via a radical process rather than concerted metalation–deprotonation.