Issue 71, 2017

H2-Driven biocatalytic hydrogenation in continuous flow using enzyme-modified carbon nanotube columns

Abstract

We describe the implementation of a system of immobilised enzymes for H2-driven NADH recycling coupled to a selective biotransformation to enable H2-driven biocatalysis in flow. This approach represents a platform that can be optimised for a wide range of hydrogenation steps and is shown here for enantioselective ketone reduction and reductive amination.

Graphical abstract: H2-Driven biocatalytic hydrogenation in continuous flow using enzyme-modified carbon nanotube columns

Supplementary files

Article information

Article type
Communication
Submitted
08 Jun 2017
Accepted
02 Aug 2017
First published
04 Aug 2017
This article is Open Access
Creative Commons BY license

Chem. Commun., 2017,53, 9839-9841

H2-Driven biocatalytic hydrogenation in continuous flow using enzyme-modified carbon nanotube columns

C. Zor, H. A. Reeve, J. Quinson, L. A. Thompson, T. H. Lonsdale, F. Dillon, N. Grobert and K. A. Vincent, Chem. Commun., 2017, 53, 9839 DOI: 10.1039/C7CC04465H

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