Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA

Mostafa Kamal Masud; Md. Nazmul Islam; Md. Hakimul Haque; Shunsuke Tanaka; Vinod Gopalan; Gursel Alici; Nam-Trung Nguyen; Alfred K. Lam; Md. Shahriar A. Hossain; Yusuke Yamauchi; Muhammad J. A. Shiddiky

doi:10.1039/C7CC04789D

Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA†

Mostafa Kamal Masud,

^ab Md. Nazmul Islam,

^bc Md. Hakimul Haque,^cd Shunsuke Tanaka,^a Vinod Gopalan,

^d Gursel Alici,

^e Nam-Trung Nguyen,

^b Alfred K. Lam,

^d Md. Shahriar A. Hossain,*^af Yusuke Yamauchi*^af and Muhammad J. A. Shiddiky

*^bc

Author affiliations

* Corresponding authors

^a Australian Institute for Innovative Materials (AIIM), University of Wollongong, Squires Way, North Wollongong, Australia

^b Queensland Micro- and Nanotechnology Centre (QMNC), Griffith University, Nathan, Australia

^c School of Natural Sciences, Griffith University, Nathan, Australia

^d Cancer Molecular Pathology Laboratory in Menzies Health Institute Queensland, Griffith University and School of Medicine, Gold Coast, Australia

^e School of Mechanical, Materials, Mechatronic and Biomedical Engineering, University of Wollongong, Wollongong, Australia

^f International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Japan

Abstract

This paper reports the development of a nonenzymatic, amplification-free, and sensitive platform for the detection of microRNA based on a new class of electrocatalytically active superparamagnetic gold-loaded nanoporous iron oxide nanocubes (Au@NPFe₂O₃NC). The assay showed an excellent detection sensitivity down to 100 fM and specificity towards the analysis of miR-21 in cell lines and tissue samples derived from patients with oesophageal squamous-cell carcinoma (ESCC).

Chemical Communications

Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA†

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Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA

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