Issue 69, 2017

pH-Sensitive metal-free carbon monoxide prodrugs with tunable and predictable release rates

Abstract

Carbon monoxide prodrugs with triggered release profiles are highly desirable for targeted CO delivery to minimize their untoward side-effects. Herein, we describe a series of pH-sensitive metal-free CO prodrugs which are stable under acidic conditions and yet begin to release CO in response to increases in pH with tunable and predictable release rates.

Graphical abstract: pH-Sensitive metal-free carbon monoxide prodrugs with tunable and predictable release rates

Supplementary files

Article information

Article type
Communication
Submitted
22 Jun 2017
Accepted
02 Aug 2017
First published
15 Aug 2017

Chem. Commun., 2017,53, 9628-9631

pH-Sensitive metal-free carbon monoxide prodrugs with tunable and predictable release rates

X. Ji, L. K. C. De La Cruz, Z. Pan, V. Chittavong and B. Wang, Chem. Commun., 2017, 53, 9628 DOI: 10.1039/C7CC04866A

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