Issue 72, 2017
From the journal:

Chemical Communications

Biotin-tagged platinum(iv) complexes as targeted cytostatic agents against breast cancer cells†

Nafees Muhammad, ORCID logo a   Nasreen Sadia,b   Chengcheng Zhu,a   Cheng Luo,a   Zijian Guo ORCID logo *a  and  Xiaoyong Wang ORCID logo *c  

* Corresponding authors

a State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China
E-mail: zguo@nju.edu.cn
Fax: +86 25 83314502
Tel: +86 25 83594549

b Department of Environmental Engineering, University of Engineering and Technology (UET), Taxila 47050, Pakistan

c State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, P. R. China
E-mail: boxwxy@nju.edu.cn
Fax: +86 25 83314502
Tel: +86 25 83594549

Abstract

A biotin-guided platinumIV complex is highly cytotoxic against breast cancer cells but hypotoxic against mammary epithelial cells. The mono-biotinylated PtIV complex is superior to the di-biotinylated one and hence a promising drug candidate for the targeted therapy of breast cancer.

Graphical abstract: Biotin-tagged platinum(iv) complexes as targeted cytostatic agents against breast cancer cells

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Supplementary files

Article information

DOI
https://doi.org/10.1039/C7CC05311H
Article type
Communication
Submitted
10 Jul 2017
Accepted
15 Aug 2017
First published
15 Aug 2017

Chem. Commun., 2017,53, 9971-9974

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Biotin-tagged platinum(IV) complexes as targeted cytostatic agents against breast cancer cells

N. Muhammad, N. Sadia, C. Zhu, C. Luo, Z. Guo and X. Wang, Chem. Commun., 2017, 53, 9971 DOI: 10.1039/C7CC05311H

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