Issue 73, 2017

Selective reduction of carboxylic acids to aldehydes with hydrosilane via photoredox catalysis

Abstract

The direct reduction of carboxylic acids to aldehydes with hydrosilane was achieved through visible light photoredox catalysis. The combination of both single electron transfer and hydrogen atom transfer steps offers a novel and convenient approach to selective reduction of carboxylic acids to aldehydes. The method also features mild conditions, high yields, broad substrate scope, and good functional group tolerance, such as alkyne, ester, ketone, amide and amine groups.

Graphical abstract: Selective reduction of carboxylic acids to aldehydes with hydrosilane via photoredox catalysis

Supplementary files

Article information

Article type
Communication
Submitted
18 Jul 2017
Accepted
18 Aug 2017
First published
18 Aug 2017

Chem. Commun., 2017,53, 10228-10231

Selective reduction of carboxylic acids to aldehydes with hydrosilane via photoredox catalysis

M. Zhang, N. Li, X. Tao, R. Ruzi, S. Yu and C. Zhu, Chem. Commun., 2017, 53, 10228 DOI: 10.1039/C7CC05570F

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