Issue 22, 2018

Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against Staphylococcus aureus

Abstract

A series of lipopeptidomimetics derived from teixobactin have been prepared that probe the role of residues (1–6) as a membrane anchor and the function of enduracididine. The most active compounds, with a farnesyl tail and End10 to Lys10 or Orn10 substitution have potent activity (MIC 8 μg mL−1) against S. aureus. These results pave the way for the synthesis of simple, cost-effective yet potent lipopeptidomimetic antimicrobials.

Graphical abstract: Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against Staphylococcus aureus

Supplementary files

Article information

Article type
Communication
Submitted
03 Aug 2017
Accepted
19 Feb 2018
First published
27 Feb 2018
This article is Open Access
Creative Commons BY license

Chem. Commun., 2018,54, 2767-2770

Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against Staphylococcus aureus

G. C. Girt, A. Mahindra, Z. J. H. Al Jabri, M. De Ste Croix, M. R. Oggioni and A. G. Jamieson, Chem. Commun., 2018, 54, 2767 DOI: 10.1039/C7CC06093A

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