SCHEDULED MAINTENANCE
A modular design for minor groove binding and recognition of mixed base pair sequences of DNA†
Pu
Guo, 
a
Ananya
Paul,
a
Arvind
Kumar,
a
Narinder K.
Harika,
a
Siming
Wang,
a
Abdelbasset A.
Farahat,
a
David W.
Boykin
a
and
W. David
Wilson
*a
a
Ananya
Paul,
a
Arvind
Kumar,
a
Narinder K.
Harika,
a
Siming
Wang,
a
Abdelbasset A.
Farahat,
a
David W.
Boykin
a
and
W. David
Wilson
*a
Abstract
The design and synthesis of compounds that target mixed, AT/GC, DNA sequences is described. The design concept connects two N-methyl-benzimidazole-thiophene single GC recognition units with a flexible linker that lets the compound fit the shape and twist of the DNA minor groove while covering a full turn of the double helix.
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