Issue 7, 2018

Coordination-driven self-assembly of a Pt(iv) prodrug-conjugated supramolecular hexagon

Abstract

This article presents a new strategy to engage coordination-driven self-assembly for platinum drug delivery. The self-assembled supramolecular hexagon is conjugated with three equivalents of Pt(IV) prodrugs and displays a superior therapeutic index compared to cisplatin against a panel of human cancer cell lines.

Graphical abstract: Coordination-driven self-assembly of a Pt(iv) prodrug-conjugated supramolecular hexagon

Supplementary files

Article information

Article type
Communication
Submitted
30 Sep 2017
Accepted
14 Dec 2017
First published
18 Dec 2017

Chem. Commun., 2018,54, 731-734

Coordination-driven self-assembly of a Pt(IV) prodrug-conjugated supramolecular hexagon

Z. Yue, H. Wang, Y. Li, Y. Qin, L. Xu, D. J. Bowers, M. Gangoda, X. Li, H. Yang and Y. Zheng, Chem. Commun., 2018, 54, 731 DOI: 10.1039/C7CC07622C

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