Issue 1, 2018

Continuous purification of active pharmaceutical ingredients utilizing polymer membrane surface wettability

Abstract

Continuous processing of pharmaceuticals opens opportunities for continuous separation based on wettability of polymer membranes. Dual use of hydrophobic and hydrophilic membranes realize in-line liquid–liquid extraction in the synthesis of four essential APIs. A secondary membrane with opposite wetting characteristics proves critical to phase separation of aqueous–organic reaction streams.

Graphical abstract: Continuous purification of active pharmaceutical ingredients utilizing polymer membrane surface wettability

Supplementary files

Article information

Article type
Communication
Submitted
24 Oct 2017
Accepted
28 Nov 2017
First published
28 Nov 2017

Chem. Commun., 2018,54, 70-73

Continuous purification of active pharmaceutical ingredients utilizing polymer membrane surface wettability

J. Imbrogno, L. Rogers, D. A. Thomas and K. F. Jensen, Chem. Commun., 2018, 54, 70 DOI: 10.1039/C7CC08218E

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