Issue 21, 2018

Copper-catalyzed three-component cyclization of amidines, styrenes, and fluoroalkyl halides for the synthesis of modular fluoroalkylated pyrimidines

Abstract

An efficient copper-catalyzed three-component cyclization for the construction of highly functionalized pyrimidine derivatives from readily available amidines, styrenes and fluoroalkyl halides is developed. This protocol distinguishes itself by the formation of three new C–C/C–N bonds and a new six-membered ring through a radical addition/oxidation/cyclization sequence in a one-pot manner.

Graphical abstract: Copper-catalyzed three-component cyclization of amidines, styrenes, and fluoroalkyl halides for the synthesis of modular fluoroalkylated pyrimidines

Supplementary files

Article information

Article type
Communication
Submitted
14 Dec 2017
Accepted
01 Feb 2018
First published
01 Feb 2018

Chem. Commun., 2018,54, 2615-2618

Copper-catalyzed three-component cyclization of amidines, styrenes, and fluoroalkyl halides for the synthesis of modular fluoroalkylated pyrimidines

X. Chu, B. Cheng, Y. Zhang, D. Ge, Z. Shen and T. Loh, Chem. Commun., 2018, 54, 2615 DOI: 10.1039/C7CC09571F

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