Issue 20, 2018

Sensitive detection of intracellular microRNA based on a flowerlike vector with catalytic hairpin assembly

Abstract

A flowerlike nanovector is developed for the fluorescence imaging and detection of miRNA in live cells with catalytic hairpin assembly. This horned vector provides a high loading efficiency of DNA amplifiers for multiple signal outputs and is applied to detect miRNA-21 in an average single HeLa cell, showing promising application in trace detection of intracellular biomolecules.

Graphical abstract: Sensitive detection of intracellular microRNA based on a flowerlike vector with catalytic hairpin assembly

Supplementary files

Article information

Article type
Communication
Submitted
14 Dec 2017
Accepted
12 Feb 2018
First published
12 Feb 2018

Chem. Commun., 2018,54, 2550-2553

Sensitive detection of intracellular microRNA based on a flowerlike vector with catalytic hairpin assembly

J. Liu, P. Du, J. Zhang, H. Shen and J. Lei, Chem. Commun., 2018, 54, 2550 DOI: 10.1039/C7CC09579A

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