Issue 5, 2018

A continuing challenge: N-heterocyclic carbene-catalyzed syntheses of γ-butyrolactones

Abstract

Catalytic, stereoselective N-heterocyclic carbene-catalyzed reactions facilitate efficient construction of many different heterocyclic compounds, such as the enantioenriched 5-membered (γ) lactones highlighted in this tutorial review. Herein, various strategies to enable formal [3+2] type annulations between electrophilic carbonyl equivalents and homoenolate nucleophiles for the synthesis of γ-lactones are summarized.

Graphical abstract: A continuing challenge: N-heterocyclic carbene-catalyzed syntheses of γ-butyrolactones

Article information

Article type
Tutorial Review
Submitted
26 May 2017
First published
26 Jan 2018

Chem. Soc. Rev., 2018,47, 1773-1782

A continuing challenge: N-heterocyclic carbene-catalyzed syntheses of γ-butyrolactones

K. J. R. Murauski, A. A. Jaworski and K. A. Scheidt, Chem. Soc. Rev., 2018, 47, 1773 DOI: 10.1039/C7CS00386B

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