Issue 18, 2018

Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging

Abstract

Abnormal enzymatic activities are directly related to the development of cancers. Identifying the location and expression levels of these enzymes in live cancer cells have considerable importance in early-stage cancer diagnoses and monitoring the efficacy of therapies. Small-molecule fluorescent probes have become a powerful tool for the detection and imaging of enzymatic activities in biological systems by virtue of their higher sensitivity, nondestructive fast analysis, and real-time detection abilities. Moreover, due to their structural tailorability, numerous small-molecule enzymatic fluorescent probes have been developed to meet various demands involving real-time tracking and visualizing different enzymes in live cancer cells or in vivo. In this review, we provide an overview of recent advances in small-molecule enzymatic fluorescent probes mainly during the past decade, including the design strategies and applications for various enzymes in live cancer cells. We also highlight the challenges and opportunities in this rapidly developing field of small-molecule fluorescent probes for interventional surgical imaging, as well as cancer diagnosis and therapy.

Graphical abstract: Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging

Article information

Article type
Review Article
Submitted
01 May 2018
First published
24 Aug 2018

Chem. Soc. Rev., 2018,47, 7140-7180

Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging

H. Liu, L. Chen, C. Xu, Z. Li, H. Zhang, X. Zhang and W. Tan, Chem. Soc. Rev., 2018, 47, 7140 DOI: 10.1039/C7CS00862G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements