Gold(I)–BODIPY–imidazole bimetallic complexes as new potential anti-inflammatory and anticancer trackable agents

Audrey Trommenschlager; Florian Chotard; Benoît Bertrand; Souheila Amor; Lucile Dondaine; Michel Picquet; Philippe Richard; Ali Bettaïeb; Pierre Le Gendre; Catherine Paul; Christine Goze; Ewen Bodio

doi:10.1039/C7DT01377A

Gold(i)–BODIPY–imidazole bimetallic complexes as new potential anti-inflammatory and anticancer trackable agents†

Audrey Trommenschlager,

^a Florian Chotard,^a Benoît Bertrand,

^a Souheila Amor,^a Lucile Dondaine,^abc Michel Picquet,

^a Philippe Richard,^a Ali Bettaïeb,^bc Pierre Le Gendre,^a Catherine Paul,^bc Christine Goze

*^a and Ewen Bodio

*^a

Author affiliations

* Corresponding authors

^a ICMUB UMR6302, CNRS, Univ. Bourgogne Franche-Comté, F-21000 Dijon, France
E-mail: ewen.bodio@u-bourgogne.fr, christine.goze@u-bourgogne.fr
Tel: +33 (0)3 80 39 60 76

^b Laboratoire d'Immunologie et Immunothérapie des Cancers, EPHE, PSL Research University, Paris, France

^c LIIC, EA7269, Université de Bourgogne Franche Comté, Dijon, France

Abstract

Two new gold(I)–BODIPY–imidazole based trackable therapeutic bimetallic complexes have been synthesized and fully characterized. They display strong antiproliferative properties on several types of cancers including colon, breast, and prostate and one of them presents a significant anti-inflammatory effect. Additionally, the two compounds could be visualised in vitro by confocal microscopy in the submicromolar range.

Dalton Transactions

Gold(i)–BODIPY–imidazole bimetallic complexes as new potential anti-inflammatory and anticancer trackable agents†

Abstract

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Gold(I)–BODIPY–imidazole bimetallic complexes as new potential anti-inflammatory and anticancer trackable agents

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