Electrochemical intramolecular dehydrogenative C–S bond formation for the synthesis of benzothiazoles

Abstract

An external oxidant-free intramolecular dehydrogenative C–S cross-coupling has been developed under undivided electrolytic conditions. Various 2-aminobenzothiazoles could be synthesized with up to 99% yield from the direct combination of aryl isothiocyanates with amines. In the presence of a base, this reaction protocol is also applicable for the synthesis of benzothiazoles from N-aryl thioamides.