Issue 5, 2017

Recent applications of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) for biological sample analysis: a follow-up review

Abstract

Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is a feasible technique to obtain either quantitative elemental data or spatially resolved imaging/mapping of elements in biological tissues. Its popularity is due to the great detection capability of the setup, which has found central applicability in metallomics, nanoparticles uptake, labeling and tagging strategies in biological systems, elemental mapping of tissues and quantitative data for biomedical studies, besides utilization in a complementary manner with molecular mass spectrometry techniques. This article provides an update of recent progress and applications of LA-ICP-MS in the biological field, covering the time frame of the last three years. Key topics dealing with fast wash-out laser ablation cell developments, novel calibration strategies such as ink printing and dried-droplets, applications and mapping of elemental distribution in biological samples (animal, human and plant tissues), nanoparticle uptake, protein and single cell analysis are surveyed and critically discussed.

Graphical abstract: Recent applications of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) for biological sample analysis: a follow-up review

Article information

Article type
Critical Review
Submitted
18 Jan 2017
Accepted
14 Mar 2017
First published
14 Mar 2017

J. Anal. At. Spectrom., 2017,32, 890-919

Recent applications of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) for biological sample analysis: a follow-up review

D. Pozebon, G. L. Scheffler and V. L. Dressler, J. Anal. At. Spectrom., 2017, 32, 890 DOI: 10.1039/C7JA00026J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements