Recent progress in the development of metal complexes as β-amyloid imaging probes in the brain

Abstract

In this review, we have focused on the recent progress in metal complexes that are able to bind to β-amyloid (Aβ) species. We have discussed various radioactive complexes of ^99mTc, ⁶⁸Ga, ⁶⁴Cu, ⁸⁹Zr, and ¹¹¹In, which were designed as Aβ imaging agents for positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging, non-radioactive Re and Ru complexes as Aβ sensors using luminescence methods, and Gd³⁺ complexes as contrast agents for magnetic resonance imaging (MRI).