Issue 11, 2017

Cancer nanomedicine: from PDGF targeted drug delivery

Abstract

An innovative approach for the distinctively efficient action of smart targeted drug delivery to a specific cell type is obtained through the modification of the surface of nanoparticles. Specifically, the work identifies a cell surface receptor targeting drug delivery nanosystem based on mesoporous silica loaded with the anticancer drug cisplatin (cis-DDP) and poly-acrylic acid (PAA). A specific target is the PDGF receptors expressed in cervical cancer cells, thus making the PAA functionalized nanocomposite a suitable and promising nano-medicine for the targeting of PDGF-overexpressing cancers in the near future.

Graphical abstract: Cancer nanomedicine: from PDGF targeted drug delivery

Supplementary files

Article information

Article type
Research Article
Submitted
31 Jul 2017
Accepted
28 Sep 2017
First published
28 Sep 2017

Med. Chem. Commun., 2017,8, 2055-2059

Cancer nanomedicine: from PDGF targeted drug delivery

C. Rejeeth, R. Vivek, V. NipunBabu, A. Sharma, X. Ding and K. Qian, Med. Chem. Commun., 2017, 8, 2055 DOI: 10.1039/C7MD00391A

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