Issue 10, 2017

Cyclometalated ruthenium complexes from naturally occurring quinones: studies on their photophysical features, computational details and trypanocidal activity

Abstract

Phenazinic ligands and Ru(II)-based complexes were synthesized from natural products lapachol and lawsone and evaluated against T. cruzi, the etiological agent of Chagas disease. These new ruthenium compounds could provide promising trypanocidal drugs. Besides synthesis and trypanocidal activity, this paper reports photophysical features and computational details of the compounds. The fluorescent trypanocidal substances are promising derivatives for further studies aiming to find molecules active against parasites associated with neglected diseases.

Graphical abstract: Cyclometalated ruthenium complexes from naturally occurring quinones: studies on their photophysical features, computational details and trypanocidal activity

Supplementary files

Article information

Article type
Paper
Submitted
01 Feb 2017
Accepted
16 Mar 2017
First published
17 Mar 2017

New J. Chem., 2017,41, 3723-3731

Cyclometalated ruthenium complexes from naturally occurring quinones: studies on their photophysical features, computational details and trypanocidal activity

C. M. de Souza, R. C. Silva, P. O. Fernandes, J. D. de Souza Filho, H. A. Duarte, M. H. Araujo, C. A. de Simone, S. L. de Castro, R. F. S. Menna-Barreto, C. P. Demicheli and E. N. da Silva Júnior, New J. Chem., 2017, 41, 3723 DOI: 10.1039/C7NJ00379J

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