Issue 13, 2017

Delivery and release of microRNA-34a into MCF-7 breast cancer cells using spherical nucleic acid nanocarriers

Abstract

Herein, we designed and prepared two sets of spherical nucleic acid (SNA) nanocarriers to deliver and release microRNA-34a (miR-34a) in MCF-7 breast cancer cells. In this strategy, survivin mRNA was used as a trigger to start the running of the SNA-based delivery system, resulting in the release of miR-34a from the SNA nanocarriers. The quantitative RT-PCR shows a significant decrease in the mRNA level and ectopic expression of miR-34a. Moreover, the released miR-34a mimics largely reduced the cell viability and induced apoptosis, suggesting the high-efficiency and availability of this SNA-based delivery system.

Graphical abstract: Delivery and release of microRNA-34a into MCF-7 breast cancer cells using spherical nucleic acid nanocarriers

Supplementary files

Article information

Article type
Letter
Submitted
13 Feb 2017
Accepted
08 May 2017
First published
09 May 2017

New J. Chem., 2017,41, 5255-5258

Delivery and release of microRNA-34a into MCF-7 breast cancer cells using spherical nucleic acid nanocarriers

H. Li, W. Shen, M. Hon-Wah Lam and H. Liang, New J. Chem., 2017, 41, 5255 DOI: 10.1039/C7NJ00510E

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