SCHEDULED MAINTENANCE
Covalent immobilisation of magnetic nanoparticles on surfaces via strain-promoted azide–alkyne click chemistry†
Raluca M.
Fratila, 
*ab
Marcos
Navascuez,
a
Javier
Idiago-López,
a
José I.
Miranda,
c
Jesús M.
Aizpurua
c
and
Jesús M.
de la Fuente
*abd
*ab
Marcos
Navascuez,
a
Javier
Idiago-López,
a
José I.
Miranda,
c
Jesús M.
Aizpurua
c
and
Jesús M.
de la Fuente
*abd
Abstract
Herein we report the synthesis of “clickable” magnetic nanoparticles (MNPs) stable in suspension in physiological media for bioorthogonal click chemistry applications. These MNPs incorporate into their coating a cyclooctynyl derivative for strain-promoted azide–alkyne (SPAAC) cycloaddition and either a polyethylene glycol or a glucose moiety to ensure MNP stability in physiological media. Their reactivity towards azide-functionalised Si surfaces was investigated, demonstrating their potential as bioorthogonal probes.
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