Issue 21, 2017

Novel construction of diversely functionalized N-heteroaryl-2-pyridones via copper(ii)-catalyzed [3+2+1] annulation

Abstract

A facile and novel one-pot construction of diversely functionalized N-heteroaryl-2-pyridones is achieved by Cu(OTf)2-catalyzed [3+2+1] annulation of various 2-aminopyridines and β-enamino esters. The [3+2+1] annulation proceeds via domino two Michael additions/elimination/isomerization/intramolecular cyclization.

Graphical abstract: Novel construction of diversely functionalized N-heteroaryl-2-pyridones via copper(ii)-catalyzed [3+2+1] annulation

Supplementary files

Article information

Article type
Paper
Submitted
14 Aug 2017
Accepted
04 Oct 2017
First published
09 Oct 2017

New J. Chem., 2017,41, 13027-13035

Novel construction of diversely functionalized N-heteroaryl-2-pyridones via copper(II)-catalyzed [3+2+1] annulation

M. S. Akhtar, J. Shim, S. H. Kim and Y. R. Lee, New J. Chem., 2017, 41, 13027 DOI: 10.1039/C7NJ03013D

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