Iodine/DMSO oxidations: a contemporary paradigm in C–N bond chemistry

Abstract

A new era in the organic synthetic world is demanding greener protocols for the execution of reactions. As the world is progressing towards fewer natural resources and high energy input, organic chemists are keeping a strict eye on seeking alternative methods to rise above these difficult situations. Amongst all reactions, oxidative reactions are the ones which require the major use of expensive metals, and harsh and toxic reagents owing to which the need of the green hour indispensably calls for a contemporary solution to existing conventional methodologies. Hereby, this review talks about the combined role of molecular iodine and DMSO in revolutionizing synthetic methodologies, especially reactions related to the oxidation process. In particular, this review highlights the construction of the C–N bond in forging biologically potent molecules through this indispensable tool.