Issue 10, 2017

MRI-guided and ultrasound-triggered release of NO by advanced nanomedicine

Abstract

Nitric oxide (NO) has been well identified as a specific free radical molecule possessing wide-ranging therapeutic effects. Targeted delivery and controlled release of NO are highly desired to realize precision gas therapy, but are still challenging owing to the non-targetability and uncontrollability of NO itself. Herein, we propose a new concept of MRI-guided and ultrasound-triggered gas release for precision gas therapy. Based on this concept, we develop a novel ultrasound-responsive BNN-type NO-releasing molecule (NORM) and an advanced rattle-type nano-carrier of superparamagnetic iron oxide-encapsulated mesoporous silica nanoparticles (SPION@hMSN), and use them to construct a new intelligent nanomedicine (BNN6-SPION@hMSN) for the first time. The BNN6-SPION@hMSN nanomedicine exhibits excellent passive tumor-targeting capability, high MRI-guided tumor localization performance and a unique ultrasound-triggered NO release profile. The tumor-targeted, MRI-guided and ultrasound-triggered release profiles of the developed nanomedicine enable the tumor site-specific controlled release of NO in favor of high-efficacy and safe NO gas therapy of tumor.

Graphical abstract: MRI-guided and ultrasound-triggered release of NO by advanced nanomedicine

Supplementary files

Article information

Article type
Paper
Submitted
11 Jan 2017
Accepted
10 Feb 2017
First published
13 Feb 2017

Nanoscale, 2017,9, 3637-3645

MRI-guided and ultrasound-triggered release of NO by advanced nanomedicine

Z. Jin, Y. Wen, Y. Hu, W. Chen, X. Zheng, W. Guo, T. Wang, Z. Qian, B. Su and Q. He, Nanoscale, 2017, 9, 3637 DOI: 10.1039/C7NR00231A

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