Issue 21, 2017

Au–Cu core–shell nanocube-catalyzed click reactions for efficient synthesis of diverse triazoles

Abstract

Au–Cu core–shell nanocubes and octahedra synthesized in aqueous solution were employed to catalyze a 1,3-dipolar cycloaddition reaction between phenylacetylene and benzyl azide in water at 50 °C for 3 h. Interestingly, the nanocubes were far more efficient in catalyzing this reaction, giving 91% yield of a regioselective 1,4-triazole product, while octahedra only recorded 46% yield. The Au–Cu nanocubes were subsequently employed to catalyze the click reaction between benzyl azide and a broad range of aromatic and aliphatic alkynes. The product yields ranged from 78 to 99%. Clearly the Au–Cu cubes exposing {100} surfaces are an excellent and green catalyst for click reactions.

Graphical abstract: Au–Cu core–shell nanocube-catalyzed click reactions for efficient synthesis of diverse triazoles

Supplementary files

Article information

Article type
Communication
Submitted
07 Apr 2017
Accepted
27 Apr 2017
First published
02 May 2017

Nanoscale, 2017,9, 6970-6974

Au–Cu core–shell nanocube-catalyzed click reactions for efficient synthesis of diverse triazoles

M. Madasu, C. Hsia and M. H. Huang, Nanoscale, 2017, 9, 6970 DOI: 10.1039/C7NR02466E

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