Issue 34, 2017

Dendrimers meet zwitterions: development of a unique antifouling nanoplatform for enhanced blood pool, lymph node and tumor CT imaging

Abstract

We report the synthesis and characterization of antifouling zwitterion carboxybetaine acrylamide (CBAA)-modified dendrimer-entrapped gold nanoparticles (Au DENPs) for enhanced CT imaging applications. The CBAA-modified nanodevice displays a better protein resistance property, less macrophage cellular uptake and liver accumulation, and longer blood half-delay time than the PEGylated counterpart material, thereby enabling enhanced blood pool, lymph node, and tumor CT imaging.

Graphical abstract: Dendrimers meet zwitterions: development of a unique antifouling nanoplatform for enhanced blood pool, lymph node and tumor CT imaging

Supplementary files

Article information

Article type
Communication
Submitted
03 Jun 2017
Accepted
31 Jul 2017
First published
01 Aug 2017

Nanoscale, 2017,9, 12295-12301

Dendrimers meet zwitterions: development of a unique antifouling nanoplatform for enhanced blood pool, lymph node and tumor CT imaging

Z. Xiong, Y. Wang, J. Zhu, X. Li, Y. He, J. Qu, M. Shen, J. Xia and X. Shi, Nanoscale, 2017, 9, 12295 DOI: 10.1039/C7NR03940A

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