Issue 31, 2017

Black TiO2 based core–shell nanocomposites as doxorubicin carriers for thermal imaging guided synergistic therapy of breast cancer

Abstract

TiO2 nanomaterials have been widely used for anticancer drug carriers and UV/980 nm NIR triggered cancer synergistic platforms. However, traditional pure TiO2 nanocarriers encounter some serious drawbacks, such as low drug loading ability, limited tissue penetration of UV light, and heating effect of 980 nm NIR on normal tissue, which obstruct their further application in cancer treatment. To overcome those challenges, novel mesoporous silica (mSiO2) coated black TiO2 core–shell nanocomposites are designed and constructed as doxorubicin carriers for 808 nm NIR triggered thermal imaging guided photothermal therapy combined chemotherapy of breast cancer. Properties of the nanocomposites such as micro-morphology, size, drug loading ability and release, targeting performance, and therapy efficiency in vitro and in vivo were evaluated. The results indicated the core–shell nanocomposites with dramatically increased loading ability were pH-responsive/NIR-accelerated doxorubicin release nanocarriers and showed synergistic breast cancer treatment in vitro and in vivo. This study verifies that the newly prepared mSiO2 coated black TiO2 core–shell nanocarriers can overcome the limitations of traditional TiO2 nanocarriers and thus improve and broaden usage of TiO2 nanoparticles in nanomedicine.

Graphical abstract: Black TiO2 based core–shell nanocomposites as doxorubicin carriers for thermal imaging guided synergistic therapy of breast cancer

Supplementary files

Article information

Article type
Paper
Submitted
07 Jun 2017
Accepted
14 Jul 2017
First published
14 Jul 2017

Nanoscale, 2017,9, 11195-11204

Black TiO2 based core–shell nanocomposites as doxorubicin carriers for thermal imaging guided synergistic therapy of breast cancer

W. Ren, M. Z. Iqbal, L. Zeng, T. Chen, Y. Pan, J. Zhao, H. Yin, L. Zhang, J. Zhang, A. Li and A. Wu, Nanoscale, 2017, 9, 11195 DOI: 10.1039/C7NR04039C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements