Issue 17, 2017

Enantioselective [4 + 1] cycloaddition of ortho-quinone methides and bromomalonates under phase-transfer catalysis

Abstract

An enantioselective [4 + 1] cycloaddition reaction of ortho-quinone methides and bromomalonates using a quinine and BINOL derived phase-transfer catalyst is described. With high yields and enantioselectivities, the method provided a variety of optically active dihydrobenzofurans, which represent a valuable structural motif present in numerous naturally occurring and biologically active molecules.

Graphical abstract: Enantioselective [4 + 1] cycloaddition of ortho-quinone methides and bromomalonates under phase-transfer catalysis

Supplementary files

Article information

Article type
Paper
Submitted
27 Feb 2017
Accepted
05 Apr 2017
First published
05 Apr 2017

Org. Biomol. Chem., 2017,15, 3670-3673

Enantioselective [4 + 1] cycloaddition of ortho-quinone methides and bromomalonates under phase-transfer catalysis

X. Lian, A. Adili, B. Liu, Z. Tao and Z. Han, Org. Biomol. Chem., 2017, 15, 3670 DOI: 10.1039/C7OB00484B

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