Issue 15, 2017

A water-soluble pillar[5]arene as a new carrier for an old drug

Abstract

The remarkable affinity of deca-carboxylatopillar[5]arene WP5 towards the aminoglycoside antibiotic, amikacin, in aqueous media is reported; in vitro studies on Gram-positive bacteria (Staphylococcus aureus) show that drug entrapment inside WP5 also takes place in the presence of the microrganisms, thus pointing to WP5 as an appealing carrier for amikacin targeted delivery.

Graphical abstract: A water-soluble pillar[5]arene as a new carrier for an old drug

Supplementary files

Article information

Article type
Communication
Submitted
02 Mar 2017
Accepted
27 Mar 2017
First published
27 Mar 2017

Org. Biomol. Chem., 2017,15, 3192-3195

A water-soluble pillar[5]arene as a new carrier for an old drug

L. Barbera, D. Franco, L. M. De Plano, G. Gattuso, S. P. P. Guglielmino, G. Lentini, N. Manganaro, N. Marino, S. Pappalardo, M. F. Parisi, F. Puntoriero, I. Pisagatti and A. Notti, Org. Biomol. Chem., 2017, 15, 3192 DOI: 10.1039/C7OB00530J

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