Issue 25, 2017

An efficient synthesis of 6-arylbenzo[4,5]imidazo[2,1-a]isoquinolines via sequential α-arylation of carbonyl and deacylation catalyzed by CuI

Abstract

Dibenzoyl methane was found to undergo α-arylation of carbonyl and deacylation reaction with 2-(2-bromophenyl)-1H-benzo[d]imidazoles catalyzed by CuI in the presence of Cs2CO3, and provided an efficient synthesis of 6-arylbenzo[4,5]imidazo[2,1-a]isoquinolines via subsequent intra-molecular nucleophilic addition and dehydration.

Graphical abstract: An efficient synthesis of 6-arylbenzo[4,5]imidazo[2,1-a]isoquinolines via sequential α-arylation of carbonyl and deacylation catalyzed by CuI

Supplementary files

Article information

Article type
Paper
Submitted
27 Apr 2017
Accepted
06 Jun 2017
First published
07 Jun 2017

Org. Biomol. Chem., 2017,15, 5325-5331

An efficient synthesis of 6-arylbenzo[4,5]imidazo[2,1-a]isoquinolines via sequential α-arylation of carbonyl and deacylation catalyzed by CuI

W. Miao, J. Liu and X. Wang, Org. Biomol. Chem., 2017, 15, 5325 DOI: 10.1039/C7OB01022B

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