Issue 44, 2017

Diffusion ordered spectroscopy (DOSY) as applied to polymers

Abstract

Diffusion ordered spectroscopy (DOSY) is a well established NMR method that reports diffusion coefficients for individual resonances in NMR spectra. DOSY is primarily used to analyse mixtures of small molecules and the oligomeric state of biomolecules. DOSY has also been used to analyse polymers and investigate micellization properties but different acquisition and processing parameters are recommended for polymers. In particular, the molecular weight dispersion of polymers and micelles are at odds with the physical limits of DOSY. Confidence in the quality of published DOSY data is lowered when critical parameters are poorly optimized or not reported. This tutorial provides a ‘top ten’ of DOSY parameters, an explanation of their source and importance, as well as suggested starting parameters and optimization for polymer/micelle samples. By following these guidelines, DOSY can emerge from being an occasional method to confirm data obtained from other experimental techniques, to one that provides strong physical evidence in its own right as the originators of DOSY intended.

Graphical abstract: Diffusion ordered spectroscopy (DOSY) as applied to polymers

Article information

Article type
Review Article
Submitted
13 Sep 2017
Accepted
25 Oct 2017
First published
25 Oct 2017

Polym. Chem., 2017,8, 6700-6708

Diffusion ordered spectroscopy (DOSY) as applied to polymers

P. Groves, Polym. Chem., 2017, 8, 6700 DOI: 10.1039/C7PY01577A

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