Issue 7, 2017

DMSO-promoted regioselective synthesis of sulfenylated pyrazoles via a radical pathway

Abstract

A facile and eco-friendly protocol for the construction of C-4 sulfenylated pyrazoles via a radical pathway was established for the first time. The reaction worked smoothly under catalyst- and solvent-free conditions to afford a wide range of sulfenylated pyrazole derivatives in good to excellent yields. The thiyl free radical generated in situ, here, also served as a single electron transfer medium for the present transformation. This reaction provides a new strategy for the formation of C–S bonds.

Graphical abstract: DMSO-promoted regioselective synthesis of sulfenylated pyrazoles via a radical pathway

Supplementary files

Article information

Article type
Research Article
Submitted
19 Mar 2017
Accepted
16 Apr 2017
First published
17 Apr 2017

Org. Chem. Front., 2017,4, 1367-1371

DMSO-promoted regioselective synthesis of sulfenylated pyrazoles via a radical pathway

P. Sun, D. Yang, W. Wei, L. Jiang, Y. Wang, T. Dai and H. Wang, Org. Chem. Front., 2017, 4, 1367 DOI: 10.1039/C7QO00218A

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