Issue 1, 2018

Asymmetric synthesis of 3-aminodihydrocoumarins via the chiral guanidine catalyzed cascade reaction of azlactones

Abstract

A highly efficient bifunctional guanidine catalyst was developed for the asymmetric cascade reaction between 2-nitrovinylphenols and azlactones. A wide variety of 3-aminodihydrocoumarin derivatives could be obtained in high yields (up to 99% yield) with excellent enantioselectivities (up to 99% ee) and diastereoselectivities (>19 : 1 dr).

Graphical abstract: Asymmetric synthesis of 3-aminodihydrocoumarins via the chiral guanidine catalyzed cascade reaction of azlactones

Supplementary files

Article information

Article type
Research Article
Submitted
29 Aug 2017
Accepted
17 Sep 2017
First published
18 Sep 2017

Org. Chem. Front., 2018,5, 32-35

Asymmetric synthesis of 3-aminodihydrocoumarins via the chiral guanidine catalyzed cascade reaction of azlactones

S. Ruan, X. Lin, L. Xie, L. Lin, X. Feng and X. Liu, Org. Chem. Front., 2018, 5, 32 DOI: 10.1039/C7QO00768J

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