Issue 4, 2018

Ball-milling and cheap reagents breathe green life into the one hundred-year-old Hofmann reaction

Abstract

The Hofmann carbylamine reaction is a very attractive route for preparing isocyanides directly from primary amines. However, its environmentally friendly potential is reduced by the use of hazardous chloroform in large excess. Herein, we report an innovative and very efficient mechanically activated synthesis of isocyanides based on the reaction of amines with chloroform in the presence of solid NaOH and without extra-solvent addition.

Graphical abstract: Ball-milling and cheap reagents breathe green life into the one hundred-year-old Hofmann reaction

Supplementary files

Article information

Article type
Research Article
Submitted
07 Nov 2017
Accepted
08 Dec 2017
First published
11 Dec 2017

Org. Chem. Front., 2018,5, 531-538

Ball-milling and cheap reagents breathe green life into the one hundred-year-old Hofmann reaction

R. Mocci, S. Murgia, L. De Luca, E. Colacino, F. Delogu and A. Porcheddu, Org. Chem. Front., 2018, 5, 531 DOI: 10.1039/C7QO01006K

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