Biosilicate scaffolds for bone regeneration: influence of introducing SrO

Cijun Shuai; Hang Sun; Ping Wu; Chengde Gao; Youwen Yang; Wang Guo; Dafeng Yang; Feng Xu; Pei Feng; Shuping Peng

doi:10.1039/C7RA01606A

Biosilicate scaffolds for bone regeneration: influence of introducing SrO

Cijun Shuai,^abc Hang Sun,^a Ping Wu,^d Chengde Gao,^a Youwen Yang,^ac Wang Guo,^a Dafeng Yang,^e Feng Xu,^e Pei Feng*^a and Shuping Peng

*^fgh

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* Corresponding authors

^a State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha, Hunan 410083, China
E-mail: fengpei@csu.edu.cn
Fax: +86-731-88879044
Tel: +86-731-84805412

^b State Key Laboratory for Powder Metallurgy, Central South University, Changsha, Hunan 410083, China

^c State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi'an, Shanxi, China

^d College of Chemistry, Xiangtan University, Xiangtan, Hunan 411105, China

^e Hunan Farsoon High-Technology Co. Ltd, Changsha, Hunan 410205, China

^f The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
E-mail: shuping@csu.edu.cn
Fax: +86-731-8887-9044
Tel: +86-731-8887-9351

^g The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan 410078, China

^h Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410078, China

Abstract

Strontium (Sr), a bioactive element in natural bone, plays a crucial role in stimulating bone remodeling and inhibiting bone resorption. In this study, strontium oxide (SrO) was incorporated into biosilicate (Mg₂SiO₄/CaSiO₃) scaffolds to improve the biological properties. The results revealed that SrO significantly enhanced cell adhesion, proliferation and the alkaline phosphatase (ALP) activity of the scaffolds. It could be explained that Sr²⁺ can stimulate osteoblast-related gene expression (osteocalcin, type I collagen, Runx2, etc.) and inhibit osteoclast differentiation. Moreover, the doped scaffolds could degrade continuously and form a dense apatite layer in SBF (simulated body fluid). Besides, the doped scaffolds possessed stable mechanical properties. However, excessive SrO led to a decrease in the strength of the scaffolds, which could be ascribed to the occurrence of unit cell volume expansion caused by the substitution of Sr²⁺ for Ca²⁺ in the CaSiO₃ lattice. Our research indicated that the SrO doped biosilicate scaffolds have great potential for application in bone regeneration.

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Biosilicate scaffolds for bone regeneration: influence of introducing SrO

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Biosilicate scaffolds for bone regeneration: influence of introducing SrO

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